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1993-01-07
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─ Area: AIDS-HIV - R ─────────────────────────────────────────────────────────
Msg#: 468 Date: 01-05-93 16:23
From: Billi Goldberg Read: Yes Replied: No
To: All Mark:
Subj: (2) CDC SUMMARY 1/4/93
──────────────────────────────────────────────────────────────────────────────
-=> Quoting Billi Goldberg to All <=-
BG> "More AIDS Patients Resistant to AZT" Washington Post (01/01/93), P.
BG> A9 Increasing numbers of AIDS patients are exhibiting early
BG> resistance to AZT, and scientists claim there is an imminent need to
BG> develop new treatments to fight HIV infection. Wendell T.W. Ching of
BG> the UCLA School of Medicine conducted a blood test study which appears
BG> in Friday's edition of the Proceedings of the National Academy of
BG> Sciences. He said blood tests are indicating more numbers of AIDS
BG> patients who have never taken AZT but are infected with a virus that
BG> is naturally resistant to the drug. "Some of the patients may have
BG> gotten the virus from other patients who had been taking AZT and who
BG> are now transmitting the resistant virus," said Ching. He added that
BG> earlier studies concluded that AZT resistance was a result of
BG> long-term use of the drug. But the new study shows that resistance
BG> may transpire naturally, even in patients who have never taken AZT,
BG> and that the resistant virus can spread from a patient who has taken
BG> the drug to another who had been disease-free. Ching said that the
BG> increase in the AZT-resistant virus may not have been found earlier
BG> due to the way blood tests were conducted. He said that researchers
BG> typically draw blood from HIV-positive people and then culture the
BG> sample until the population of the virus has increased. While this
BG> occurs, there is a change in the relative numbers of different
BG> strains of the HIV, which appears to hide the dominance of
BG> AZT-resistant strains. Ching and his colleagues corrected the problem
BG> by drawing blood from patients and testing for different strains of
BG> HIV before the virus had a chance to grow new generations.
BG> -!-
BG> * The GrapeVine/Ferret Face BBS * NLR,ARK * 501-753-8121 DS *
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